Is it legal to use human-derived exosomes for skin rejuvenation in the UK? The answer depends more on who you ask. Many UK professionals are of the opinion that, as long as you only use them topically (i.e., applying them to the skin, rather than injecting them), it's OK. The U.S. Food and Drug Administration (FDA) has authority to regulate regenerative medicine products, including stem cell products and exosome products. There is a lot of misleading information on the Internet about these products, including statements about the conditions they can be used for.
The FDA is concerned that many patients seeking cures and remedies may be deceived by information about products that are illegally marketed, that have not been proven to be safe or effective and, in some cases, that may present significant safety issues that put patients at risk. The FDA wants to help consumers be informed about how these products are regulated and what they should consider when considering treatment with one of these products. products. As no exosome has been approved by organizations such as the Food and Drug Association (FDA) or the MHRA, they are not allowed to be injected, but they can be legally applied, either topically or using microneedles.
Yes, exosome therapy is legal in the UK when it is administered by qualified professionals in a regulated clinical environment. At Premier Laser Clinic, we comply with all relevant guidelines and regulations to ensure the safety and effectiveness of our treatments. The legality of using exosomes of human origin for skin rejuvenation in the UK is subject of debate. While some professionals argue that topical application of exosomes is allowed, concerns arise when exosomes are used topically in conjunction with procedures such as micropuncture, designed to improve skin care penetration.
In addition, according to British and European regulations, the use of ingredients of human origin is strictly prohibited, making the use of exosomes of human origin illegal, even for topical applications. The ambiguity surrounding this topic underscores the importance of careful consideration before undergoing such treatments. Unlike that of cells, which can be uncontrollable with varying therapeutic efficacy, the biological response of exosomes is safe and more predictable. Exosome therapy combined with a derma roller is an emerging and innovative solution for treating balding hair.
Exosomes are thought to remain active in the skin for up to six to eight months after treatment, contributing to a sustained improvement in skin quality. Many customers find that microneedling with exosomes is highly effective in improving skin texture, reducing fine lines, combating imperfections and promoting a youthful appearance. Finally, the availability of exosomes as a commercial product would represent a significant paradigm shift towards the use of autologous products in cosmetics (table). Although the duration of the effect may be shorter, exosomes do not have cell-like proliferation or differentiation capabilities, but they can store and transport biological substances for efficient and targeted delivery.
This review aims to elucidate the current and future landscape of exosomes and topical peptides as therapeutic agents for skin rejuvenation, including future FDA approval. Analysis using nanoparticle tracking, transmission electron microscopy and western blot is often used to determine the character, morphology and protein content of exosomes. A literature search was carried out using the keywords “peptides” or “exosomes” and “skin” or “rejuvenation”. With advances in medical technology, extracellular vesicles, also known as exosomes, are receiving widespread attention because of their potential therapeutic applications.
Government, there are hundreds of ongoing clinical trials related to exosomes in a wide range of medical specialties, indicating a recent increase in interest in exosomes. Exosomes, tiny extracellular vesicles produced naturally by nearly every cell in the body, act as crucial agents in intercellular communication. Recently, extracellular vesicles, such as stem cell exosomes, have been explored and promoted, as a form of personalized medicine. When analyzing aesthetic improvement, Ye et al discovered that treatment with exosomes improved the roughness, peeling and erythema score of sensitive skin, as well as burning, tension, itching and dryness, as evaluated by a professional dermatologist based on an objective and subjective sensitive skin index.
For this reason, techniques for extracting exosomes from a cell type are not likely to be the solution for others.
