Stem cells, together with anti-aging genes such as Klotho, play a crucial role in delaying the aging process. Stem cells, in combination with anti-aging genes, form a complex protective shield that resists the erosive effects of aging. With our current knowledge of stem cells, it is technically possible to delay aging and improve both health and life expectancy. Stem cells can play a crucial role in delaying the aging process.
Stem cells, in combination with anti-aging genes, can create a sophisticated shield that can prevent the effects of aging. The sales pitch here is simple. If I give you an IV that contains young stem cells, it will make you younger. The genesis of this concept is based on a small piece of science that has been greatly amplified by influential people and social media celebrities, as well as by a growing number of doctors who, in my humble opinion, are playing the short game of get rich quickly.
Loss of elasticity, laxity, wrinkles, and the appearance of a rough texture are characteristics of skin aging. How to counteract it? Stem cells can help restore skin quality by providing collagen and elastin “factories”, removing the limits of botox and fillers. Researchers have made a scientific discovery that, over time, could be used to delay the signs of aging. Stem cell therapy, using exosomes, can contribute to a younger appearance by improving skin rejuvenation, improving elasticity, and reducing signs of aging, such as fine lines and wrinkles.
However, the results may vary from person to person. Stem cells hold great promise for regenerative therapies for a wide spectrum of diseases and disorders of aging because of their ability to regenerate tissues and contribute to their homeostasis. Aging is associated with a marked decline in these adult stem cell functionalities. Therefore, the regeneration of aged tissues is less efficient and less effective than that of young tissues. Recent studies have revealed the remarkably dynamic responses of stem cells to systemic signals, including the ability of “juvenile factors” in the blood of young animals to improve the functionality of aging stem cells.
Therefore, there is high hope that even aging stem cells will retain remarkable regenerative potential if they are provided with the right signals and environment to initiate tissue repair. The general objective of the presentations in this session is to address the determinants of changes in stem cell functionality with age, the key characteristics of stem cells in aging tissues, the extent to which those characteristics can be rejuvenated and by what signals, and the potential of stem cell therapy for chronic diseases and acute injuries in older people. To the extent that chronic diseases could be treated by replacing dysfunctional cells with functional cells from the same tissue, stem cell therapy holds promise for age-related diseases. Like the age-related changes themselves, it's critical to understand how stem cells contribute to or combat age-related diseases. George Daley, a leading biologist specializing in stem cells who is dean of Harvard Medical School, wrote in response to Salk's article that “it was necessary to rigorously demonstrate this effect in order to be able to say that reprogramming is a true anti-aging intervention.
In the case of things like adipose stromal vascular fraction or autologous mesenchymal stem cells from bone marrow expanded in culture, although the FDA considers them drugs, after a period of safety testing resulting in publications, their use is likely to be safe abroad, where regulations would classify these procedures as a medical practice. In recent years, ²³ researchers have discovered that stem cell-derived exosomes have enormous potential in skin care, in particular for anti-aging treatments. The potential benefits of stem cells as anti-aging therapy include cell rejuvenation, improved organ function, and reduced risk of age-related diseases. This is because if we can make cells act younger, healthier and more resilient, we may have a general-purpose means of preventing many diseases at once. Therefore, for scientists and doctors, it represents a unique challenge for the approach aimed at delaying, preventing or reversing pathological processes, since cell replacement is not part of normal biology.
These are all examples of cells that are reprogrammed from age to youth, exactly the phenomenon that companies like Altos want to capture, to bottle and sell someday. It is clear that understanding the basic biology of stem cells and how that biology changes with age has great potential in terms of therapeutic dividends derived from investment in basic research. Scientific advances in this area are among the most important bridges between the study of stem cells and the study of the biology of aging and age-related diseases. It is also important to note that stem cells are not a magic solution and their use should be approached with caution and under the supervision of a qualified medical professional.
However, many questions remain to be addressed in this field, in particular with regard to the relationship and contribution of the stem cell compartment to the structure and function of adult tissue. Because exosomes are derived from stem cells, they work with the body's own healing processes to repair and rejuvenate the skin, providing subtle yet significant results without the need for harsh chemicals or synthetic materials.
