We identified a variety of novel chemical cocktails capable of rejuvenating cells and reversing transcript aging to a degree similar to OSK overexpression. Therefore, it is possible to reverse aspects of aging without erasing cellular identity using chemical rather than genetic means. Experts from King's College London have discovered a genetic signature of around 150 genes that can evaluate the human aging process. Other researchers are measuring telomeres, the protective covers found at the ends of chromosomes, such as the plastic tips of shoelaces, to protect DNA.
After age 40, you can lose eight percent of your muscle mass every decade, slowing your metabolism and weakening your body, so consolidate good habits right from the start. Research from Japan's National Center for Global Health and Medicine suggests that a traditional Japanese diet rich in fish rich in omega 3 reduces the mortality rate by 15 percent. A study published in the British Journal of Nutrition suggested that switching to a Mediterranean-style diet with fish, vegetables, whole grains and unrefined carbohydrates, even later in life, reduces mortality from any cause by 25 percent. For an antioxidant effect, try their body-boosting green smoothie, made with three handfuls of kale, two celery branches, two apples, ¼ avocado, 1 teaspoon ground flaxseed and water.
A study published in Biological Psychiatry found that lack of sleep increased inflammatory markers related to cardiovascular disease, hypertension and type 2 diabetes, while a US study suggested that people who sleep less than five hours a night had “excessive heart age” 5.1 years older than their real age. Sinclair, from Harvard Medical School, the University of Maine and the Massachusetts Institute of Technology (MIT), published a new priority research article on aging, entitled “Chemically Induced Reprogramming to Reverse Cellular Aging.” Before you can know if a treatment can slow or even reverse aging, you must first know how quickly a person ages. The Glenn Center for Research in the Biology of Aging at Harvard Medical School describes a revolutionary aging clock that can accelerate or reverse cell aging. Sinclair is currently testing the system in the laboratory with human neurons, skin and fibroblasts, which contribute to connective tissue.
More broadly, Wyss-Coray's findings support the idea that at least some of the consequences of aging are reversible. The cells in the two panels on the right have re-established the compartmentalization of the red fluorescent protein in the nucleus, a marker of youth that was used to find the cocktails, before scientists confirmed that they were younger, based on the way in which the genes were expressed. By developing a chemical alternative to reversing age through gene therapy, this research could revolutionize the treatment of aging, injuries and age-related diseases, and could reduce costs and shorten time frames of development. Academics are divided between “programmed theories”, in which human beings follow a biological calendar of genetic, hormonal and immune decline, and “theories related to damage”, according to which environmental and lifestyle factors cause DNA damage, inflammation or oxidative stress that damages cells.
Scientists who study aging have debated what drives the senescence process in cells and have focused primarily on DNA mutations that, over time, can alter the normal functioning of a cell and trigger the process of cell death. Sinclair has long proposed that aging is the result of losing the fundamental instructions that cells need to keep functioning, in what he calls information theory about aging. The restart came in the form of gene therapy involving three genes that command cells to reprogram themselves. In the case of mice, instructions guided the cells to restart the epigenetic changes that defined their identity, such as kidney and skin cells, two types of cells prone to the effects of aging. Scientists have also been researching the use of CAR T-cell therapy in treating non-cancerous diseases, such as autoimmune diseases and viral infections such as HIV and hepatitis C.
Because all cells have the same DNA pattern, the epigenome is what causes skin cells to become skin cells and brain cells to brain cells. Research from the University of Miami shows that ginger has an anti-inflammatory effect on cells, while a study published in the Saudi Medical Journal suggests that a daily dose can improve cholesterol levels. Corina Amor Vegas, adjunct professor at the Cold Spring Harbor Laboratory (CSHL) and lead author of this study, said they focused on T cells as a potential way to combat aging because the immune system is very powerful in eliminating damaged cells in younger people.
